Iodine → 6-Phenyl-2-pyridin-2-ylmethyl-isothiazolo[5,4-d]pyrimidin-3-one

반응식

[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][NH:8][C:9]([C:11]1[C:12]([SH:23])=[N:13][C:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[N:15][CH:16]=1)=[O:10].II>>[C:17]1([C:14]2[N:13]=[C:12]3[S:23][N:8]([CH2:7][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=4)[C:9](=[O:10])[C:11]3=[CH:16][N:15]=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

반응물 2

HCID 807Iodine

HCID 1784182364-Mercapto-2-phenyl-pyrimidine-5-carboxylic acid (pyridin-2-ylmethyl)-amide

생성물 1

HCID 232879016-Phenyl-2-pyridin-2-ylmethyl-isothiazolo[5,4-d]pyrimidin-3-one수율 81.6%

실험 절차

Using the procedure of Example 20, 2.0 g (6.20 mmol) of 4-mercapto-2-phenyl-pyrimidine-5-carboxylic acid (pyridin-2-ylmethyl)-amide were treated with 1.73 g (6.82 mmol) of iodine to give 1.62 g of the title compound after recrystallization from isopropanol, mp 154-156° C.

출처 및 근거

ORD 기록: ord-9a0858b42aa7429498769176d1e0ceae
출처 데이터셋: uspto-grants-1999_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06001863

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