4-Propylbenzaldehyde → 8-(p-Propylphenyl)-7-octenenitrile

HRID 611669

반응식

HRID 611669 반응식
[Br-].[C:2]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)#[N:3].[CH2:29]([C:32]1[CH:39]=[CH:38][C:35]([CH:36]=O)=[CH:34][CH:33]=1)[CH2:30][CH3:31]>C1COCC1>[CH2:29]([C:32]1[CH:39]=[CH:38][C:35]([CH:36]=[CH:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:2]#[N:3])=[CH:34][CH:33]=1)[CH2:30][CH3:31]

참가 물질

4

반응물 2

HCID 1200474-PropylbenzaldehydeHCID 187950896-Cyanohexyltriphenylphosphonium bromide

생성물 1

HCID 538329298-(p-Propylphenyl)-7-octenenitrile수율 67.3%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

This compound was synthesized from 6-cyanohexyltriphenylphosphonium bromide (9.05 g, 20 mmol) and p-propylbenzaldehyde (2.96 g, 20 mmol) in THF (100 mL) by a Wittig reaction. Kugelrohr distillation afforded the product (3.25 g, 67%) as a colorless liquid (bp 144-148° C./0.05 torr). IR 2290 cm-1 ; 1H-NMR: 0.95 (t, 3 H), 1.55 (m, 8 H), 2.40 (m, 6 H), 5.60 (m, 1 H), 6.40 (d, 1H), 7.10 (s, 4 H).

후처리

  1. distillationKugelrohr distillation

출처 및 근거

ORD 기록
ord-fabaac7e463047a9905efec4f5705413
출처 데이터셋
uspto-grants-1999_12
특허 번호
US06001869

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