Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
o-Aminophenethyl alcohol → HCID 22466588, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | o-Aminophenethyl alcohol | HCID 79282 | — |
| 반응물 | Pyridinium chloride | HCID 10176127 | — |
| 반응물 | 4-Chloro-6,7-dimethoxy-quinoline-3-carbonitrile | HCID 10586676 | — |
| 용매 | Glycol monoethyl ether | HCID 8076 | — |
| 생성물 | HCID 22466588 | HCID 22466588 | 64.4% |
반응 단계
Using an analogous procedure to that described in Example 286, 248.7 mg (1 mmol) of 4-chloro-6,7-dimethoxy-3-quinolinecarbonitrile in 12 mL of 2-ethoxyethanol and in the presence of 115.6 mg (1 mmol) of pyridine hydrochloride was reacted with 178.3 mg (1.3 mmol) of 2-aminophenethyl alcohol to give 218.4 mg (64.4%) of the product as a pink solid, m.p 159-162° C., mass (electrospray, m/e): M+H 349.9.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06002008 |
| 출처 데이터셋 | uspto-grants-1999_12 |
| ORD ID | ord-a4fe963d86a540b1b24a71a3bfef6269 |
| 출처 메모 | uspto-grants-1999_12 |