Potassium Hydroxide → 2-Furancarboxylic acid, 5-methyl-

HRID 612302

반응식

HRID 612302 반응식
[CH3:1][C:2]1[O:6][C:5]([C:7]([O:9]C)=[O:8])=[CH:4][CH:3]=1.[OH-].[K+]>CO.O>[CH3:1][C:2]1[O:6][C:5]([C:7]([OH:9])=[O:8])=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 137628Methyl 5-methyl-2-furancarboxylate

생성물 1

HCID 747102-Furancarboxylic acid, 5-methyl-수율 94.1%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

Methyl 5-methyl-2-furoate (3.68 g, 26.29 mmol) in methanol (30 ml) was treated with a solution of potassium hydroxide (2.80 g, 50.0 mmol) in water (15 ml) and the mixture stirred for 2 h at room temperature. The methanol was evaporated in vacuo, the residue dissolved in water and washed with ethyl acetate. The aqueous phase was acidified with SN hydrochloric acid, and the product extracted with ethyl acetate (x3). The combined organic solutions were dried and concentrated to yield the title compound as a yellow solid (3.12 g, 94%); m.p. 110-112° C.; (Found: M+, 126.0312. C6H6O3 requires M+ 126.0317); νmax (CH2C12) 3300-2700, 1688, 1524, 1424, 1305, 1210 and 1167 cm-1 ; δH (CDCl3, 90 MHz) 2.40 (3 H, s), 6.15 (1 H, d, J 4 Hz) and 7.22 (1 H, d, J 4 Hz).

후처리

  1. customThe methanol was evaporated in vacuo
  2. dissolutionthe residue dissolved in water
  3. washwashed with ethyl acetate
  4. extractionthe product extracted with ethyl acetate (x3)
  5. customThe combined organic solutions were dried
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-876d93a4846146a4966eb33d7b266495
출처 데이터셋
uspto-grants-1999_12
특허 번호
US06001997

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