참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Benzamide | HCID 2331 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | (Z)-1,4-dibromobut-2-ene | HCID 5354994 | — |
| 촉매 | Tetrabutylammonium Bromide | HCID 74236 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 1H-Pyrrole, 1-benzoyl-2,5-dihydro- | HCID 11252283 | — |
반응 단계
121 g (1 mol) of benzamide in 3 l of toluene are introduced initially, 200 g of powdered potassium hydroxide are introduced with stirring, 32 g (0.1 mol) of tetrabutylammonium bromide are added and the mixture is heated to 40° C. 243 g (1 mol) of 88% cis-1,4-dibromo-2-butene are then added dropwise in such a way that the internal temperature does not exceed 60° C. The mixture is stirred for another 5 hours at 50° C., then poured into water, and the organic phase is separated off, washed with water, dried and concentrated. The residue is distilled under reduced pressure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06004956 |
|---|
| 출처 데이터셋 | uspto-grants-1999_12 |
|---|
| ORD ID | ord-cd9b215d99da4c52ba807717bb4107ea |
|---|
| 출처 메모 | uspto-grants-1999_12 |
|---|
