Benzyl Bromide → 2-benzyl-4,5-dibromopyridazin-3(2H)-one

HRID 612398노트

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HRID 612398 반응식
[Br:1][C:2]1[C:7]([Br:8])=[CH:6][N:5]=[N:4][CH:3]=1.N1NC(=[O:15])C=CC=1.[CH2:16](Br)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[OH-].[K+]>CN(C=O)C>[CH2:16]([N:4]1[C:3](=[O:15])[C:2]([Br:1])=[C:7]([Br:8])[CH:6]=[N:5]1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

5

반응물 3

HCID 7498Benzyl BromideHCID 14797Potassium HydroxideHCID 698350204,5-dibromopyridazin 2H-pyridazin-3-one

생성물 1

HCID 99026992-benzyl-4,5-dibromopyridazin-3(2H)-one

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
50 °C

실험 절차

A mixture of 4,5-dibromopyridazin-2H-pyridazin-3-one (10 g, 40 mmol), benzyl bromide (6.84 g, 40 mmol), 8N KOH (5 mL, 40 mmol) and DMF (40 mL) was warmed up to 50° C. and reacted for 0.5 hr. The mixture was cooled to r.t., poured over H20 (500 mL) and extracted twice with Et2O (200 mL). The combined organic layers were washed with brine, dried with MgSO4 and the solvent was removed in vacuo to give the title compound which was used for next step without further purification.

후처리

  1. customreacted for 0.5 hr
  2. temperatureThe mixture was cooled to r.t.
  3. additionpoured over H20 (500 mL)
  4. extractionextracted twice with Et2O (200 mL)
  5. washThe combined organic layers were washed with brine
  6. dry with materialdried with MgSO4
  7. customthe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-712d01db5d3a44ffb703264df5dee842
출처 데이터셋
uspto-grants-1999_12
특허 번호
US06004960

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