Water → 2-benzyl-4,5-dibromopyridazin-3(2H)-one

HRID 612399노트

반응식

HRID 612399 반응식
[C:1](O)(=O)/[C:2](=[C:4](\[CH:6]=[O:7])/[Br:5])/[Br:3].Cl.Cl.[CH2:12]([NH:19][NH2:20])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.O>C(O)C>[CH2:12]([N:19]1[C:6](=[O:7])[C:4]([Br:5])=[C:2]([Br:3])[CH:1]=[N:20]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 146540Benzylhydrazine dihydrochlorideHCID 3033972Mucobromic Acid

생성물 1

HCID 99026992-benzyl-4,5-dibromopyridazin-3(2H)-one수율 54.4%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Alternatively, a suspension of mucobromic acid (80 g., 310 mmol.) and benzylhydrazine dihydrochloride (60 g., 310 mmol.) in ethanol was heated to reflux for 16 hours. It was cooled to r.t. and under vigourous stirring water (50 mL) was added. The suspension was cooled in an ice bath and then filtered. The solid was washed with 95% aqueous ethanol and air dried. It was swished in hexanes (200 mL) and diethyl ether (25 mL), filtered and air dried to yield the title compound(58 g.).

후처리

  1. temperaturewas heated
  2. temperatureto reflux for 16 hours
  3. additionwas added
  4. temperatureThe suspension was cooled in an ice bath
  5. filtrationfiltered
  6. washThe solid was washed with 95% aqueous ethanol and air
  7. customdried
  8. filtrationdiethyl ether (25 mL), filtered
  9. customair dried

출처 및 근거

ORD 기록
ord-21e0d7d408fb4ae98056a12957933a83
출처 데이터셋
uspto-grants-1999_12
특허 번호
US06004960

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