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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 61246생성일: 2026년 10월 24일

2-Chloro-5-(trifluoromethyl)pyrimidine → (S)-(4,4-Difluoro-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone

https://huagongshe.com/reaction/61246

반응식

참여 물질

역할이름HCID투입량
반응물2-Chloro-5-(trifluoromethyl)pyrimidineHCID 13317019—
반응물5-Methyl-2-(pyrimidin-2-yl)benzoic acidHCID 44517264—
반응물2-((4,4-Difluoropiperidin-2-yl)methyl)isoindoline-1,3-dioneHCID 117728017—
생성물(S)-(4,4-Difluoro-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanoneHCID 117727662—

반응 단계

The title compound was prepared following the same general protocol as described for Example A210 using 2-((4,4-difluoropiperidin-2-yl)methyl)isoindoline-1,3-dione and 5-methyl-2-(pyrimidin-2-yl)benzoic acid and Example A45 using 2-chloro-5-(trifluoromethyl)pyrimidine. ESI-MS (m/z): 493 (M+H).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09440982B2
출처 데이터셋uspto-grants-2016_09
ORD IDord-911f1feac7ab449b9ad60381a434343f
출처 메모uspto-grants-2016_09