Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Glycine → 4-((4-Fluorophenyl)methylene)-2-methyl-5(4H)-oxazolone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Glycine | HCID 750 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | 4-Fluorobenzaldehyde | HCID 68023 | — |
| 반응물 | Sodium Acetate | HCID 517045 | — |
| 용매 | Acetic Anhydride | HCID 7918 | — |
| 생성물 | 4-((4-Fluorophenyl)methylene)-2-methyl-5(4H)-oxazolone | HCID 367073 | 78.6% |
반응 단계
With stirring, 7.5 g (0.1 mol) of glycine with 6.2 g (0.075 mol) of anhydrous sodium acetate and 18.6 g (0.15 mol) of p-fluorobenzaldehyde in 60 ml of acetic anhydride are heated to 100° C. After 2 hours, the reaction is cooled and poured into water. The resulting precipitate is filtered off with suction and dried under reduced pressure. 12.1 g (59% of theory) of 2-methyl-4-(4-fluorobenzylidene)-oxazol-5-one of mp. 156° C. are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06004992 |
| 출처 데이터셋 | uspto-grants-1999_12 |
| ORD ID | ord-6a124d6a9c454b1db81f3ca950d6acaf |
| 출처 메모 | uspto-grants-1999_12 |