3-Methoxyphenyl isocyanate → N-(2-hydroxy-4-nitrophenyl)-N'-(3-methoxyphenyl)urea

HRID 612636노트

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HRID 612636 반응식
[OH:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[CH3:12][O:13][C:14]1[CH:15]=[C:16]([N:20]=[C:21]=[O:22])[CH:17]=[CH:18][CH:19]=1>>[OH:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH:4][C:21]([NH:20][C:16]1[CH:17]=[CH:18][CH:19]=[C:14]([O:13][CH3:12])[CH:15]=1)=[O:22]

참가 물질

3

반응물 2

HCID 878433-Methoxyphenyl isocyanateHCID 49847212-Amino-5-Nitrophenol

생성물 1

HCID 21184674N-(2-hydroxy-4-nitrophenyl)-N'-(3-methoxyphenyl)urea수율 46.2%

실험 절차

N-(2-Hydroxy-4-nitrophenyl)-N'-(3-methoxyphenyl)urea was prepared from 2-hydroxy 4-nitro aniline (154 mg, 1.0 mmol) and 3-methoxy phenyl isocyanate (1.0 mmol) according to the procedure in General Method B. The product was purified by dilution with methylene chloride and precipitation with hexanes. Filtering afforded the title compound (140 mg, 46%). EI-MS m/z 302 (M-H)-

후처리

  1. customThe product was purified by dilution with methylene chloride and precipitation with hexanes
  2. filtrationFiltering

출처 및 근거

ORD 기록
ord-10b2416ca5fd4b2c8be6fd83a277ebef
출처 데이터셋
uspto-grants-1999_12
특허 번호
US06005008

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