1-Isocyanato-2-phenylbenzene → N-(2-hydroxy-4-trifluoromethylphenyl) N'-(2-phenylphenyl)urea

HRID 612653

반응식

HRID 612653 반응식
[OH:1][C:2]1[CH:8]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[C:13]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[N:25]=[C:26]=[O:27])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[OH:1][C:2]1[CH:8]=[C:7]([C:9]([F:10])([F:11])[F:12])[CH:6]=[CH:5][C:3]=1[NH:4][C:26]([NH:25][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:27]

참가 물질

3

반응물 2

HCID 2222801-Isocyanato-2-phenylbenzeneHCID 155242772-Amino-5-(trifluoromethyl)phenol

생성물 1

HCID 22011313N-(2-hydroxy-4-trifluoromethylphenyl) N'-(2-phenylphenyl)urea수율 65%

실험 절차

The urea was prepared from 2-hydroxy 4-trifluoromethyl aniline (example 7a, 0.171 g, 1 mmol) and 2-phenyl phenyl isocyanate by general Method B. It was purified by dilution with methylene chloride and precipitation with hexane. Filtering afforded the desired compound (0.24 g, 65%). EI-MS m/z 373 (M+H)}hu +

후처리

  1. customIt was purified by dilution with methylene chloride and precipitation with hexane
  2. filtrationFiltering

출처 및 근거

ORD 기록
ord-e7603576d5204be2b15bb06091987332
출처 데이터셋
uspto-grants-1999_12
특허 번호
US06005008

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