4-Fluoro-3-methoxymethoxy-5-phenylisoxazole → HCID 178519001, 화합물

HRID 612924노트

반응식

HRID 612924 반응식
[F:1][C:2]1[C:3]([O:13]COC)=[N:4][O:5][C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>Cl.O1CCOCC1>[F:1][C:2]1[C:3]([OH:13])=[N:4][O:5][C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

참가 물질

3

반응물 1

HCID 195967054-Fluoro-3-methoxymethoxy-5-phenylisoxazole

생성물 1

HCID 178519001HCID 178519001, 화합물수율 84.9%

시약·촉매·용매 1

HCID 204431481,4-Dioxane hydrochloride용매

실험 절차

4-Fluoro-3-methoxymethoxy-5-phenylisoxazole (0.44 g) was dissolved in a solution of 4N hydrochloric acid/dioxane (5.0 ml), and the solution was stirred at room temperature for one hour. After the reaction, the solvent was evaporated under reduced pressure and the crystal thus obtained was washed with dichloromethane (10 ml) to obtain the title compound (0.30 g, 83%) as colorless crystals.

후처리

  1. customAfter the reaction
  2. customthe solvent was evaporated under reduced pressure
  3. customthe crystal thus obtained
  4. washwas washed with dichloromethane (10 ml)

출처 및 근거

ORD 기록
ord-3a43b3fe7e1247b4bd4d2510ffd293a6
출처 데이터셋
uspto-grants-1999_12
특허 번호
US06005116

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