Triethylamine → HCID 131737170, 화합물

HRID 61315

반응식

HRID 61315 반응식
[C:1]1([CH:9]=[CH:10][C:11](Cl)=[O:12])[C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[CH:2]=1.C(N(CC)CC)C.[CH3:21][CH2:22][C:23]([CH2:28][O:29][CH2:30][CH:31]=[CH2:32])([CH2:26][OH:27])[CH2:24][OH:25]>C1(C)C=CC=CC=1>[CH3:21][CH2:22][C:23]([CH2:26][O:27][CH2:4][CH:1]=[CH2:2])([CH2:28][O:29][CH2:30][CH:31]=[CH2:32])[CH2:24][OH:25].[C:1]1([CH:9]=[CH:10][C:11]([OH:12])=[O:25])[C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[CH:2]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 12683Trimethylolpropane monoallyl etherHCID 178521137HCID 178521137, 화합물

생성물 1

HCID 131737170HCID 131737170, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

The procedure of Example 8 was repeated except that the following amounts of materials were used: BCB-AA acid chloride from Example 6 (40.98 g, 212.7 mmol), toluene (200 mL), triethylamine (29.11 g, 287.7 mmol) and trimethylolpropane allyl ether (18.18 g, 104.3 mmol). The product was isolated as a clear orange colored viscous oil. Yield: 36.02 g (71.6%). 1H NMR (500 MHz, Chloroform-d) δ 7.68 (d, J=15.9 Hz, 2H), 7.35 (dd, J=7.6, 1.4 Hz, 2H), 7.24 (s, 2H), 7.06 (d, J=7.6 Hz, 2H), 6.39 (d, J=16.0 Hz, 2H), 5.89 (ddt, J=17.2, 10.7, 5.5 Hz, 1H), 5.37-5.23 (m, 1H), 5.17 (dd, J=10.4, 1.6 Hz, 1H), 4.25 (d, J=2.1 Hz, 4H), 3.98 (d, J=5.5 Hz, 2H), 3.44 (s, 2H), 3.19 (s, 8H), 1.59 (q, J=7.6 Hz, 2H), 0.96 (t, J=7.6 Hz, 3H).

후처리

  1. customThe product was isolated as a clear

출처 및 근거

ORD 기록
ord-bfbb588137ae4e35a72505f5363d96ee
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09441055B1

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