HCID 601959, 화합물 → 3-(Trimethylsilyl)aniline

HRID 613164노트

반응식

HRID 613164 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([Si:10]([CH3:13])([CH3:12])[CH3:11])[CH:7]=[CH:8][CH:9]=1)([O-])=O>C1C=CC=CC=1.[Pd]>[CH3:11][Si:10]([CH3:13])([CH3:12])[C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=1)[NH2:1]

참가 물질

4

반응물 1

HCID 601959HCID 601959, 화합물

생성물 1

HCID 124888833-(Trimethylsilyl)aniline수율 99.8%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 241Benzene용매

실험 절차

m-Nitrotrimethylsilylbenzene (200 mg) was catalytically hydrogenated over Pd-C in 7.5 ml of benzene at atmospheric pressure for 40 minutes. The catalyst was filtered off and washed with benzene and dry MeOH, successively. The filtrate and washings were mixed and evaporated. The residue was purified by column chromatography on silica gel [eluent: methylene chloride] to give 169 mg of pale brown liquid.

후처리

  1. filtrationThe catalyst was filtered off
  2. washwashed with benzene and dry MeOH
  3. additionThe filtrate and washings were mixed
  4. customevaporated
  5. customThe residue was purified by column chromatography on silica gel [eluent: methylene chloride]

출처 및 근거

ORD 기록
ord-be8e1c4277a6405fb0eb9eb935f16fc3
출처 데이터셋
uspto-grants-1999_12
특허 번호
USRE036477

반응 노트

불러오는 중…