N-(tert-butoxycarbonyl)-L-aspartic acid → (S)-tert-Butyl (2,5-dioxotetrahydrofuran-3-yl)carbamate
반응식
[C:1]([O:5][C:6]([NH:8][C@H:9]([C:14]([OH:16])=[O:15])[CH2:10][C:11]([OH:13])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2]>O1CCCC1>[C:1]([O:5][C:6]([NH:8][C@@H:9]1[C:14](=[O:15])[O:16][C:11](=[O:13])[CH2:10]1)=[O:7])([CH3:2])([CH3:3])[CH3:4]참가 물질
3
실험 절차
To a solution of 23.3 g N-t-butyloxycarbonyl-L-aspartic acid in 150 mL of tetrahydrofuran was added portionwise 20.6 g of N,N-dicyclohexyl-carbodiimide at 0° C. and overnight at room temperature. The precipitated dicyclohexyl urea was filtered off and all solvent was evaporated under reduced pressure. The oily residue was crystallized from acetone/hexane to give 18.24 g of anydride as white needles.
후처리
- customovernight
- customat room temperature
- filtrationThe precipitated dicyclohexyl urea was filtered off
- customall solvent was evaporated under reduced pressure
- customThe oily residue was crystallized from acetone/hexane
- customto give 18.24 g of anydride as white needles
출처 및 근거
- ORD 기록
- ord-671e327625df43ec844fd6ebc60ff142
- 출처 데이터셋
- uspto-grants-1999_12
- 특허 번호
- US06008058
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