Morpholine → 6-(Morpholine-4-carbonyl)nicotinic acid, t-butyl ester

HRID 613233노트

반응식

HRID 613233 반응식
[N:1]1[CH:6]=[C:5]([C:7]([O-:9])=[O:8])[CH:4]=[CH:3][C:2]=1[C:10]([O:12]C)=O.[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>O1CCCC1>[N:14]1([C:10]([C:2]2[CH:3]=[CH:4][C:5]([C:7]([O:9][C:5]([CH3:7])([CH3:6])[CH3:4])=[O:8])=[CH:6][N:1]=2)=[O:12])[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 425561312,5-Pyridinedicarboxylic acid, 2-methyl ester

생성물 1

HCID 100857186-(Morpholine-4-carbonyl)nicotinic acid, t-butyl ester

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

For example, the 2,5-pyridinedicarboxylic acid, 2-methyl ester, 5-t-butyl ester (11) is contacted with a molar excess of morpholine in an appropriate organic solvent, such as tetrahydrofuran. The reaction is typically conducted at a temperature range of from room temperature to reflux and for a period of time ranging from 5 hours to 3 days. The 6-(morpholine-4-carbonyl)nicotinic acid, t-butyl ester (12) is isolated from the reaction mixture by standard extractive methods as is known in the art and may be purified by crystallization.

후처리

  1. customis typically conducted at a temperature range of from room temperature
  2. temperatureto reflux and for a period of time
  3. waitranging from 5 hours to 3 days

출처 및 근거

ORD 기록
ord-e1e56a8925d9495baf0e37ec1db3f616
출처 데이터셋
uspto-grants-1999_12
특허 번호
US06008196

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