Thionyl Chloride → 3-Pyridin-3-ylpropanoyl chloride
반응식
S(Cl)([Cl:3])=O.[N:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH2:11][CH2:12][C:13]([OH:15])=O)[CH:6]=1>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1.ClCCCl>[N:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH2:11][CH2:12][C:13]([Cl:3])=[O:15])[CH:6]=1참가 물질
5
실험 절차
Add thionyl chloride (0.05 mL, 0.53 mmol) to a stirred suspension of 3-(3-pyridyl)propionic acid (80.2 mg, 0.53 mmol) and benzyltriethylammonium chloride (1 mg, 0.004 mmol) in 1,2-dichloroethane (20 mL) and heat to reflux for 2.5 hours. Cool the reaction mixture to room temperature and concentrate in vacuo. Azeotrope the residue with CCl4 and place under vacuum. Use the resulting acid chloride without further purification.
후처리
- temperatureheat
- temperatureto reflux for 2.5 hours
- concentrationconcentrate in vacuo
- customwithout further purification
출처 및 근거
- ORD 기록
- ord-da6f477ca9344f2ab17f08116fd10489
- 출처 데이터셋
- uspto-grants-1999_12
- 특허 번호
- US06008196
반응 노트
불러오는 중…