[1-(1,2-Dimethyl-propyl)-4-methyl-cyclohex-3-enyl]-methanol → 4-(1,2-Dimethyl-propyl)-1-methyl-2-oxa-bicyclo[2.2.2]octane

HRID 61329노트

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HRID 61329 반응식
[CH3:1][CH:2]([C:6]1([CH2:13][OH:14])[CH2:11][CH2:10][C:9]([CH3:12])=[CH:8][CH2:7]1)[CH:3]([CH3:5])[CH3:4]>C1(C)C=CC=CC=1>[CH3:1][CH:2]([C:6]12[CH2:11][CH2:10][C:9]([CH3:12])([CH2:8][CH2:7]1)[O:14][CH2:13]2)[CH:3]([CH3:4])[CH3:5]

참가 물질

3

반응물 1

HCID 89705124[1-(1,2-Dimethyl-propyl)-4-methyl-cyclohex-3-enyl]-methanol

생성물 1

HCID 897054244-(1,2-Dimethyl-propyl)-1-methyl-2-oxa-bicyclo[2.2.2]octane수율 54.5%

시약·촉매·용매 1

HCID 1140Toluene용매

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온도
60 °C

실험 절차

[1-(1,2-Dimethyl-propyl)-4-methyl-cyclohex-3-enyl]-methanol (268 g, obtained as detailed above), MSA (10 g), and toluene (300 mL) were charged to a 2 L reaction flask, heated to 60° C., and aged for 12 hours. The reaction mixture was cooled, washed with saturated sodium carbonate solution, and distilled to provide 4-(1,2-dimethyl-propyl)-1-methyl-2-oxa-bicyclo[2.2.2]octane (146 g).

후처리

  1. temperatureThe reaction mixture was cooled
  2. washwashed with saturated sodium carbonate solution
  3. distillationdistilled

출처 및 근거

ORD 기록
ord-5ac573a873e940709e164533c4b7567b
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09441185B2

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