2-Heptanol → Cyclopropanecarboxylic acid 1-methyl-hexyl ester
반응식
[CH3:1][CH:2]([OH:8])[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[CH:9]1([C:12](O)=[O:13])[CH2:11][CH2:10]1>C1(C)C=CC(S(O)(=O)=O)=CC=1.C1(C)C=CC=CC=1>[CH3:1][CH:2]([O:8][C:12]([CH:9]1[CH2:11][CH2:10]1)=[O:13])[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]참가 물질
5
실험 절차
2-Heptanol (200 g, 1.72 mol) and cyclopropanecarboxylic acid (163 g, 1.90 mol) were added into toluene (500 mL), followed by p-toluenesulfonic acid (3.2 g, 0.0172 mol). The reaction mixture was heated to reflux for 6 hours, cooled to room temperature, and quenched with aqueous sodium bicarbonate (1 L). The reaction mixture was then washed with brine (0.5 L) and dried over sodium sulfate (50 g). The solvent was removed and the reaction mixture was distilled to provide the product cyclopropanecarboxylic acid 1-methyl-hexyl ester (253 g).
후처리
- temperatureThe reaction mixture was heated
- temperatureto reflux for 6 hours
- customquenched with aqueous sodium bicarbonate (1 L)
- washThe reaction mixture was then washed with brine (0.5 L)
- dry with materialdried over sodium sulfate (50 g)
- customThe solvent was removed
- distillationthe reaction mixture was distilled
출처 및 근거
- ORD 기록
- ord-59cafe26ff9e483eae52495a7a1c2ddb
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09441185B2
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