Isoprene → 4-Cyclohexene-1,2-dicarboxylic acid, 4-methyl-, dimethyl ester

HRID 61342

반응식

HRID 61342 반응식
[CH2:1]=[CH:2][C:3](=[CH2:5])[CH3:4].[C:6]([O:14][CH3:15])(=[O:13])/[CH:7]=[CH:8]\[C:9]([O:11][CH3:12])=[O:10]>>[CH3:12][O:11][C:9]([CH:8]1[CH2:1][CH:2]=[C:3]([CH3:5])[CH2:4][CH:7]1[C:6]([O:14][CH3:15])=[O:13])=[O:10]

참가 물질

3

반응물 2

HCID 6557IsopreneHCID 5271565Dimethyl maleate

생성물 1

HCID 2743794-Cyclohexene-1,2-dicarboxylic acid, 4-methyl-, dimethyl ester수율 66.7%

반응 조건

온도
150 °C

실험 절차

Isoprene (350 g, 5.1 mol) and dimethyl maleate (741 g, 5.1 mol) were loaded into a stainless steel autoclave. The autoclave was sealed and heated to 150° C. The temperature of the autoclave increased to 195° C. due to the heat of the reaction. The temperature was held at 160° C. for 1 hour. Gas chromatography (GC) analysis indicated the completion of the reaction. The autoclave was then cooled to room temperature. Simple distillation of the resulting mixture provided 4-methyl-cyclohex-4-ene-1,2-dicarboxylic acid dimethyl ester (725 g, 3.4 mol, 66% yield) as a light yellow liquid.

후처리

  1. customThe autoclave was sealed
  2. temperatureThe temperature of the autoclave increased to 195° C. due to the
  3. temperatureheat of the reaction
  4. customthe completion of the reaction
  5. temperatureThe autoclave was then cooled to room temperature
  6. distillationSimple distillation of the resulting mixture

출처 및 근거

ORD 기록
ord-eba05cae420d4eb5ae930194eb321a31
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09441185B2

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