Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium methanethiolate → HCID 19592663, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium methanethiolate | HCID 4378561 | — |
| 반응물 | 3-Bromoquinolin-8-amine | HCID 15112545 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | HCID 19592663 | HCID 19592663 | 66.2% |
반응 단계
A mixture of 8-amino-3-bromoquinoline (200 mg) and sodium thiomethoxide (109 mg) in N,N-dimethylformamide (2 ml) was stirred at ambient temperature for 2 days. After diluted with ethyl acetate, the resulting mixture was washed with water and brine, dried over anhydrous sodium sulfate, and evaporated in vacuo. The residue was purified by chromatography on silica gel (n-hexane-ethyl acetate) to give 8-amino-3-methylthioquinoline (113 mg) as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06008230 |
| 출처 데이터셋 | uspto-grants-1999_12 |
| ORD ID | ord-802c2d8881664f5886a4efecce353081 |
| 출처 메모 | uspto-grants-1999_12 |