3-Methoxy-4-nitrobenzyl alcohol → (4-Amino-3-methoxyphenyl)methanol

HRID 613594노트

반응식

HRID 613594 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[N+:11]([O-])=O)[CH2:6][OH:7].[H][H]>[Pd].CO>[NH2:11][C:10]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][C:3]=1[O:2][CH3:1]

참가 물질

5

반응물 2

HCID 6029613-Methoxy-4-nitrobenzyl alcoholHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 53420748(4-Amino-3-methoxyphenyl)methanol수율 108.8%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 3-methoxy-4-nitrobenzyl alcohol (1.0 g) and 10% palladium on carbon (100 mg) in methanol was stirred for 2 hours under 3 atmospheric pressure of hydrogen. After filtration, the filtrate was concentrated in vacuo to give 4-amino-3-methoxybenzyl alcohol (910 mg) as an oil.

후처리

  1. filtrationAfter filtration
  2. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-91bce1332ac54aae9e0c19f0f9b55334
출처 데이터셋
uspto-grants-1999_12
특허 번호
US06008229

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