Trimethylamine → Methyl 3-[2-[2-(5-methyl-2-thienyl)ethoxy]ethylaminosulphonyl]propanoate

HRID 613747노트

반응식

HRID 613747 반응식
[CH3:1][C:2]1[S:6][C:5]([CH2:7][CH2:8][O:9][CH2:10][CH2:11][NH2:12])=[CH:4][CH:3]=1.CN(C)C.Cl[S:18]([CH2:21][CH2:22][C:23]([O:25][CH3:26])=[O:24])(=[O:20])=[O:19]>ClCCl>[CH3:1][C:2]1[S:6][C:5]([CH2:7][CH2:8][O:9][CH2:10][CH2:11][NH:12][S:18]([CH2:21][CH2:22][C:23]([O:25][CH3:26])=[O:24])(=[O:20])=[O:19])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 1146TrimethylamineHCID 4962888Methyl 3-(chlorosulfonyl)propanoateHCID 195934942-[2-(5-Methyl-2-thienyl)ethoxy]ethanamine

생성물 1

HCID 18779053Methyl 3-[2-[2-(5-methyl-2-thienyl)ethoxy]ethylaminosulphonyl]propanoate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

The product of step c) as the hydrochloride salt (1.50 g) was stirred under nitrogen in dichloromethane (25 ml). Trimethylamine (2.21 ml) was added followed by methyl 3-(chlorosulphonyl)propanoate (1.18 g). The mixture was stirred at room temperature overnight. The solution was diluted with a further amount of dichloromethane and the organics washed with dilute hydrochloric acid then water, then dried (MgSO4). The mixture was filtered and the volatiles removed in vacuo to give the subtitle compound as an oil (1.4 g).

후처리

  1. washthe organics washed with dilute hydrochloric acid
  2. dry with materialwater, then dried (MgSO4)
  3. filtrationThe mixture was filtered
  4. customthe volatiles removed in vacuo

출처 및 근거

ORD 기록
ord-1dbb62a917d041cc8842c69e3cb41c8b
출처 데이터셋
uspto-grants-1999_12
특허 번호
US06008365

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