Dimethylformamide → HCID 20563052, 화합물

HRID 613982

반응식

HRID 613982 반응식
N[C:2]1[O:3][C:4]2[CH:14]=[CH:13][CH:12]=[CH:11][C:5]=2[C:6](=[O:10])[C:7]=1C=O.[C:15]([C:17]#[CH:18])#[N:16].[CH3:19][N:20](C)C=O>>[C:15]([C:17]1[CH:19]=[N:20][C:7]2[C:6](=[O:10])[C:5]3[C:4]([O:3][C:2]=2[CH:18]=1)=[CH:14][CH:13]=[CH:12][CH:11]=3)#[N:16]

참가 물질

4

반응물 3

HCID 6228DimethylformamideHCID 140552-PropynenitrileHCID 7359282-Amino-3-formylchromone

생성물 1

HCID 20563052HCID 20563052, 화합물

반응 조건

온도
140 °C

실험 절차

To 70 ml of dimethylformamide was added 2.2 g of 2-amino-4-oxo-4H-1-benzopyran-3-carboxaldehyde, followed by the addition of 2.5 g of cyanoacetylene. The mixture was heated under stirring at 140° C. for 15 hours and the solvent was then distilled off under reduced pressure. The residue was chromatographed on silica gel and eluted with chloroform and recrystallized from acetonitrile to give 0.83 g of 3-cyano-1-azaxanthone as crystals, m.p. 220°-226° C.

후처리

  1. temperatureThe mixture was heated
  2. distillationthe solvent was then distilled off under reduced pressure
  3. customThe residue was chromatographed on silica gel
  4. washeluted with chloroform
  5. customrecrystallized from acetonitrile

출처 및 근거

ORD 기록
ord-53216e11e18842ada0acdfc09a4e3e2b
출처 데이터셋
uspto-grants-1979_03
특허 번호
US04143042

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