8-Chloro-4-methyl-2-phenyl-3,4-dihydropyrido[3,2-F][1,4]oxazepin-5(2H)-one → 8-[3-Methoxy-4-(4-methylimidazol-1-yl)anilino]-4-methyl-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-5-one

HRID 614

반응식

HRID 614 반응식
CN1CC(c2ccccc2)Oc2nc(Cl)ccc2C1=O.COc1cc(N)ccc1-n1cnc(C)c1.Cl>CC(=O)O.CC(=O)O.COCCOC.O=C([O-])[O-].[Cs+].[Cs+].[Pd].c1ccc(-c2ccccc2P(C2CCCCC2)C2CCCCC2)cc1>COc1cc(Nc2ccc3c(n2)OC(c2ccccc2)CN(C)C3=O)ccc1-n1cnc(C)c1

참가 물질

7

반응물 2

HCID 595778258-Chloro-4-methyl-2-phenyl-3,4-dihydropyrido[3,2-F][1,4]oxazepin-5(2H)-oneHCID 674242353-Methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline hydrochloride

생성물 1

HCID 498200868-[3-Methoxy-4-(4-methylimidazol-1-yl)anilino]-4-methyl-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-5-one수율 40.02%

시약·촉매·용매 4

HCID 10796Cesium carbonate시약HCID 27342162-(Dicyclohexylphosphino)biphenyl촉매HCID 4144353Palladium (II) acetate촉매HCID 80711,2-Dimethoxyethane용매

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온도
100 °C

실험 절차

were placed in a microwave vial equipped with a stirring bar. The vial was capped and flushed with argon. DME (2 mL) and Et3N (0.028 mL, 0.20 mmol) were added via a syringe and the mixture was stirred at room temperature for 30 min and then heated to 100°C in a microwave apparatus for 1h. The reaction mixture was diluted with dichloromethane and ethyl acetate, fitered and concentrated. The residue was purified by reversed phase HPLC to give 37 mg of the product as a solid.

출처 및 근거

ORD 기록
ord-322a5f0c927a43d5b08115d8443f975d
출처 데이터셋
750 AstraZeneca ELN dataset
원본 링크
출처 보기

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