Benzene → 2-Cyano-2-(2,4-dichlorophenyl)hexyl methane sulfonate

HRID 614070노트

반응식

HRID 614070 반응식
[C:1]([C:3]([C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][C:11]=1[Cl:17])([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:4][OH:5])#[N:2].[CH3:18][S:19](Cl)(=[O:21])=[O:20].C1C=CC=CC=1>C(N(CC)CC)C>[CH3:18][S:19]([O:5][CH2:4][C:3]([C:1]#[N:2])([C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][C:11]=1[Cl:17])[CH2:6][CH2:7][CH2:8][CH3:9])(=[O:21])=[O:20]

참가 물질

5

반응물 3

HCID 241BenzeneHCID 31297Methanesulfonyl chlorideHCID 233399042-Cyano-2-(2,4-dichlorophenyl)hexan-1-ol

생성물 1

HCID 233399252-Cyano-2-(2,4-dichlorophenyl)hexyl methane sulfonate

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

A mixture of 2-cyano-2-(2,4-dichlorophenyl)hexan-1-ol (5.6g., 0.02 mole) and methane sulfonyl chloride (2.9g., 0.025 mole) in 200 ml. of benzene is added dropwise at 10° C., 2.8g. (0.027) of triethylamine. The reaction mixture is stirred at room temperature for 30 minutes and then heated on a steam bath for another 30 minutes. The precipitate formed is filtered and the filtrate is washed with dilute hydrochloric acid, water, saturated sodium bicarbonate solution, saturated sodium chloride solution and dried over magnesium sulfate. The solvent is evaporated to give 6.3g. of product.

후처리

  1. temperatureheated on a steam bath for another 30 minutes
  2. customThe precipitate formed
  3. filtrationis filtered
  4. washthe filtrate is washed with dilute hydrochloric acid, water, saturated sodium bicarbonate solution, saturated sodium chloride solution
  5. dry with materialdried over magnesium sulfate
  6. customThe solvent is evaporated
  7. customto give 6.3g

출처 및 근거

ORD 기록
ord-d357bb61589c472ca22042a6a8f944c7
출처 데이터셋
uspto-grants-1979_03
특허 번호
US04143137

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