Ethyl (3-Hydroxyphenyl)acetate → Ethyl 3[(2-nitro-3-phenylbenzofuran-5-yl)methoxy]phenylacetate

HRID 614097노트

반응식

HRID 614097 반응식
[O-]CC.[Na+].[OH:5][C:6]1[CH:7]=[C:8]([CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH:9]=[CH:10][CH:11]=1.Br[CH2:19][C:20]1[CH:21]=[CH:22][C:23]2[O:27][C:26]([N+:28]([O-:30])=[O:29])=[C:25]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[C:24]=2[CH:37]=1>C(O)C>[N+:28]([C:26]1[O:27][C:23]2[CH:22]=[CH:21][C:20]([CH2:19][O:5][C:6]3[CH:7]=[C:8]([CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH:9]=[CH:10][CH:11]=3)=[CH:37][C:24]=2[C:25]=1[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)([O-:30])=[O:29]

참가 물질

5

반응물 3

HCID 572437Ethyl (3-Hydroxyphenyl)acetateHCID 2723922Sodium ethoxideHCID 13531604HCID 13531604, 화합물

생성물 1

HCID 20333822Ethyl 3[(2-nitro-3-phenylbenzofuran-5-yl)methoxy]phenylacetate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 0.0066 ml. of sodium ethoxide in 50 ml. of ethanol is added 1.2 g. (0.0066 mole) of ethyl 3-hydroxyphenylacetate. The mixture is heated at its reflux temperature for three hours, then 2 g. (0.006 mole) of 5-bromomethyl-2-nitro-3-phenylbenzofuran is added. The mixture is heated at its reflux temperature for 16 hours. On cooling of the reaction mixture a yellow precipitate is obtained which is separated by filtration. Recrystallization from a mixture of hexane and benzene provides ethyl 3[(2-nitro-3-phenylbenzofuran-5-yl)methoxy]phenylacetate, m.p. 67°-68° C.

후처리

  1. temperatureThe mixture is heated at its
  2. temperaturereflux temperature for three hours
  3. temperatureThe mixture is heated at its
  4. temperaturereflux temperature for 16 hours
  5. temperatureOn cooling of the reaction mixture a yellow precipitate
  6. customis obtained which
  7. customis separated by filtration
  8. customRecrystallization
  9. additionfrom a mixture of hexane and benzene

출처 및 근거

ORD 기록
ord-dd1327e4cf284c2393352acf37b51bc9
출처 데이터셋
uspto-grants-1979_03
특허 번호
US04143154

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