Butyl isocyanate → HCID 178449847, 화합물

HRID 614343노트

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HRID 614343 반응식
[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([N:10]3[C:14]4=[N:15][CH:16]=[CH:17][CH:18]=[C:13]4[NH:12][C:11]3=[O:19])=[CH:4][C:3]=2[O:2]1.[CH2:20]([N:24]=[C:25]=[O:26])[CH2:21][CH2:22][CH3:23].C1OC2C=CC(N3C4=NC=CC=C4NC3=O)=CC=2[O:28]1.C(C(N)=O)CCC>C(COC)OC>[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([N:10]3[C:14]4=[N:15][CH:16]=[CH:17][CH:18]=[C:13]4[NH:12][C:11]3=[O:19])=[CH:4][C:3]=2[O:2]1.[CH2:20]([N-:24][C:25]([OH:28])=[O:26])[CH2:21][CH2:22][CH3:23]

참가 물질

5

반응물 3

HCID 8110Butyl isocyanateHCID 119617392H-Imidazo[4,5-b]pyridin-2-one, 3-(1,3-benzodioxol-5-yl)-1,3-dihydro-HCID 131711457HCID 131711457, 화합물

생성물 1

HCID 178449847HCID 178449847, 화합물

시약·촉매·용매 1

HCID 80711,2-Dimethoxyethane용매

실험 절차

A suspension of 1.2 g. of 1,3-dihydro-3-(3,4-methylenedioxyphenyl)imidazo[4,5-b]pyridin-2-one in 75 ml. of dry dimethoxyethane was treated with 1 g. of n-butyl isocyanate and refluxed until solution was complete. The solution was filtered and evaporated to near dryness and diluted with petroleum ether. The precipitate was recrystallized from 30 ml. of ethanol by addition of water to give 400 mg. of 1,3-dihydro-3-(3,4-methylenedioxyphenyl)-2-oxoimidazo[4,5-b]pyridine-1-n-butylcarboxamide,. m.p. 129°-130° C.

후처리

  1. additionA suspension of 1.2 g
  2. filtrationThe solution was filtered
  3. customevaporated
  4. additiondiluted with petroleum ether
  5. customThe precipitate was recrystallized from 30 ml
  6. additionof ethanol by addition of water
  7. customto give 400 mg

출처 및 근거

ORD 기록
ord-4c0556a970b14a9f9ae67bf663002da8
출처 데이터셋
uspto-grants-1979_03
특허 번호
US04144341

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