Butyl bromide → HCID 21329306, 화합물

HRID 614347노트

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HRID 614347 반응식
[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([N:10]3[C:14]4=[N:15][CH:16]=[CH:17][CH:18]=[C:13]4[NH:12][C:11]3=[O:19])=[CH:4][C:3]=2[O:2]1.[OH-].[K+].Br[CH2:23][CH2:24][CH2:25][CH3:26]>CC(C)=O>[CH2:23]([N:12]1[C:13]2[C:14](=[N:15][CH:16]=[CH:17][CH:18]=2)[N:10]([C:5]2[CH:6]=[CH:7][C:8]3[O:9][CH2:1][O:2][C:3]=3[CH:4]=2)[C:11]1=[O:19])[CH2:24][CH2:25][CH3:26]

참가 물질

5

반응물 3

HCID 8002Butyl bromideHCID 14797Potassium HydroxideHCID 119617392H-Imidazo[4,5-b]pyridin-2-one, 3-(1,3-benzodioxol-5-yl)-1,3-dihydro-

생성물 1

HCID 21329306HCID 21329306, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a suspension of 2.6 g. (0.01 mole) of 1,3-dihydro-3-(3,4-methylenedioxyphenyl)imidazo[4,5-b]-pyridin-2-one in 150 ml. of acetone, was added 1.12 g. (0.02 mole) of powdered potassium hydroxide. The mixture was stirred at room temperature for 20 minutes and 2.74 g. (0.02 mole) of 1-bromobutane was added. The mixture was stirred at reflux for 16 hours and then evaporated in vacuo. The residue was extracted with a solution of 20 ml. of 2.5 N sodium hydroxide and 50 ml. of water. The product was separated by filtration and was purified by crystallization from ether-petroleum ether giving 2.4 g. of white needles melting at 74°-75° C.

후처리

  1. additionTo a suspension of 2.6 g
  2. stirringThe mixture was stirred
  3. temperatureat reflux for 16 hours
  4. customevaporated in vacuo
  5. extractionThe residue was extracted with a solution of 20 ml
  6. customThe product was separated by filtration
  7. customwas purified by crystallization from ether-petroleum ether giving 2.4 g

출처 및 근거

ORD 기록
ord-c3ca62fefccb47778086dfc0f31d5ffc
출처 데이터셋
uspto-grants-1979_03
특허 번호
US04144341

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