Ethyl 2-oxopyrrolidine-1-acetate → N-[2-Methyl-2-(piperidin-1-yl)propyl]-2-(2-oxopyrrolidin-1-yl)acetamide

반응식

[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]([O:10]CC)=O.[CH3:13][C:14]([N:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1)([CH3:17])[CH2:15][NH2:16]>>[CH3:17][C:14]([N:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1)([CH3:13])[CH2:15][NH:16][C:8](=[O:10])[CH2:7][N:3]1[CH2:4][CH2:5][CH2:6][C:2]1=[O:1]

참가 물질

반응물 2

HCID 109094Ethyl 2-oxopyrrolidine-1-acetate

HCID 17131182-Methyl-2-(piperidin-1-yl)propan-1-amine

생성물 1

HCID 44374414N-[2-Methyl-2-(piperidin-1-yl)propyl]-2-(2-oxopyrrolidin-1-yl)acetamide

실험 절차

From 8.56 g. of ethyl 2-oxo-1-pyrrolidineacetate and 12.5 g. of 2-methyl-2-(1-piperidinyl)propylamine [J.A.C.S. 68, 13 (1946)], following the procedure of Example 9, there is obtained N-[2-methyl-2-(1-piperidinyl)propyl]-2-oxo-1-pyrrolidineacetamide; m.p. 69° C. after crystallization from heptane.

출처 및 근거

ORD 기록: ord-7b7826809fbe4374b0c97127aaba5189
출처 데이터셋: uspto-grants-1979_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04145347

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