Nitric Acid → HCID 12909298, 화합물

HRID 614527노트

반응식

HRID 614527 반응식
[CH:1]1[N:9]2[C:4]([CH2:5][O:6][C:7]3[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=32)=[N:3][C:2]=1[C:14]([O:16][CH3:17])=[O:15].S(=O)(=O)(O)O.[N+:23]([O-])([OH:25])=[O:24]>O>[N+:23]([C:11]1[CH:12]=[CH:13][C:7]2[O:6][CH2:5][C:4]3=[N:3][C:2]([C:14]([O:16][CH3:17])=[O:15])=[CH:1][N:9]3[C:8]=2[CH:10]=1)([O-:25])=[O:24]

참가 물질

5

반응물 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 12909280HCID 12909280, 화합물

생성물 1

HCID 12909298HCID 12909298, 화합물수율 79%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

8.0 g of methyl 4H-imidazo-[2,1-c][1,4]-benzoxazine-2-carboxylate were added to a stirred mixture of 25 ml of concentrated sulfuric acid and 25 ml of concentrated nitric acid at 10° C. The ester slowly went into solution with the solution turning yellow and after three hours at room temperature, thin layer chromatography indicated no starting material remained. 500 ml of water were then added and the yellow product thus formed was filtered off, washed well with water and then dried over P2O5 to obtain 7.5 g (79% yield) of methyl 8-nitro-4H-imidazo-[2,1-c][1,4]-benzoxazine-2-carboxylate with a melting point of 270°-2° C.

후처리

  1. customthe yellow product thus formed
  2. filtrationwas filtered off
  3. washwashed well with water
  4. dry with materialdried over P2O5

출처 및 근거

ORD 기록
ord-8ada9dd7c86d47a29bfcb9bf802d0b66
출처 데이터셋
uspto-grants-1979_03
특허 번호
US04145419

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