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Dichloromethane → (3s,5s,6s)-5-(Methoxycarbonyl)-1-methyl-6-[(4-phenyl-3,6-dihydropyridin-1(2h)-yl)carbonyl]piperidin-3-yl piperidine-1-carboxylate

HRID 61456
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HRID 61456 반응식
[OH:1][C@@H:2]1[CH2:7][N:6]([CH3:8])[C@H:5]([C:9]([N:11]2[CH2:16][CH:15]=[C:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH2:13][CH2:12]2)=[O:10])[C@@H:4]([C:23]([O:25][CH3:26])=[O:24])[CH2:3]1.C(Cl)Cl.C1N=CN([C:35]([N:37]2[CH:41]=N[CH:39]=[CH:38]2)=[O:36])C=1.N1CCC[CH2:44][CH2:43]1>>[N:37]1([C:35]([O:1][C@H:2]2[CH2:3][C@H:4]([C:23]([O:25][CH3:26])=[O:24])[C@@H:5]([C:9]([N:11]3[CH2:12][CH:13]=[C:14]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[CH2:15][CH2:16]3)=[O:10])[N:6]([CH3:8])[CH2:7]2)=[O:36])[CH2:38][CH2:39][CH2:44][CH2:43][CH2:41]1
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참가 물질

5

반응물 4

HCID 6344DichloromethaneHCID 8082PiperidineHCID 682631,1'-CarbonyldiimidazoleHCID 67304114Methyl (2s,3s,5s)-5-hydroxy-1-methyl-2-[(4-phenyl-3,6-dihydropyridin-1(2h)-yl)carbonyl]piperidine-3-carboxylate

생성물 1

HCID 67304225(3s,5s,6s)-5-(Methoxycarbonyl)-1-methyl-6-[(4-phenyl-3,6-dihydropyridin-1(2h)-yl)carbonyl]piperidin-3-yl piperidine-1-carboxylate

실험 절차

A solution of methyl(2S,3S,5S)-5-hydroxy-1-methyl-2-[(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl]piperidine-3-carboxylate (72 mg, 0.00020 mol) in methylene chloride (2.0 mL, 0.031 mol) was treated with N,N-carbonyldiimidazole (50 mg, 0.0003 mol) at rt for 2 h. To the mixture was added piperidine (0.060 mL, 0.00060 mol). After stirred at rt overnight, the mixture was concentrated to dry and used directly in next step.

후처리

  1. concentrationthe mixture was concentrated
  2. customto dry

출처 및 근거

ORD 기록
ord-9313db97b17140319bef5b7980514fb1
출처 데이터셋
uspto-grants-2016_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09440958B2

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