Benzyl Alcohol → Benzyl mesylate
반응식
[CH2:1]([OH:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[CH3:16][S:17](Cl)(=[O:19])=[O:18]>ClCCl>[CH3:16][S:17]([O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)(=[O:19])=[O:18]참가 물질
5
실험 절차
To an ice cooled solution of 54 g (0.5 mol) of benzyl alcohol and 75.75 g (104.3 ml, 0.75 mol) of triethylamine in 1800 ml of dichloromethane is added dropwise 63 g (42.57 ml, 0.55 mol) of methanesulfonyl chloride. The temperature of the reaction mixture during the addition is ca. 10°. The reaction mixture is then stirred for 1.5 hours at 10°. The reaction mixture is then diluted with dichloromethane, washed with ice water, cold 10% HCl, saturated KHCO3, saturated NaCl and dried (MgSO4). Solvent is removed in vacuo to yield the benzyl methanesulfonate as an oil.
후처리
- additionThe temperature of the reaction mixture during the addition
- customis ca. 10°
- washwashed with ice water, cold 10% HCl, saturated KHCO3, saturated NaCl
- dry with materialdried (MgSO4)
- customSolvent is removed in vacuo
출처 및 근거
- ORD 기록
- ord-142440ae98ad4ede98e4142a5d04f31d
- 출처 데이터셋
- uspto-grants-1979_03
- 특허 번호
- US04145433
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