Resorcinol → 2-Ethyl-4-(3-trifluoromethylphenyl)-7-hydroxy-2-methyl-2H-chromene

HRID 614749

반응식

[CH2:1]([C:3]1([CH3:15])[CH2:12][C:11](=O)[C:10]2[C:5](=[CH:6][C:7]([OH:14])=[CH:8][CH:9]=2)[O:4]1)[CH3:2].C1(C=CC=C(O)C=1)O.B(F)(F)F.CCOCC.C1C=CC2OCCC(=O)C=2C=1.[F:44][C:45]([F:55])([F:54])[C:46]1[CH:47]=[C:48]([Mg]Br)[CH:49]=[CH:50][CH:51]=1>>[CH2:1]([C:3]1([CH3:15])[CH:12]=[C:11]([C:50]2[CH:49]=[CH:48][CH:47]=[C:46]([C:45]([F:55])([F:54])[F:44])[CH:51]=2)[C:10]2[C:5](=[CH:6][C:7]([OH:14])=[CH:8][CH:9]=2)[O:4]1)[CH3:2]

참가 물질

반응물 5

HCID 5054Resorcinol

HCID 8000Boron trifluoride etherate

HCID 68110Chromanone

HCID 205705082-Ethyl-7-hydroxy-2-methyl-4-chromanone

HCID 178506173HCID 178506173, 화합물

생성물 1

HCID 205705652-Ethyl-4-(3-trifluoromethylphenyl)-7-hydroxy-2-methyl-2H-chromene

실험 절차

2-Ethyl-7-hydroxy-2-methyl-4-chromanone, m.p. 109°-110.5° C., was prepared by condensing resorcinol with 3-methyl-2-pentanoic acid in the presence of boron trifluoride diethyl etherate. Reaction of the chromanone with 3-trifluoromethylphenyl magnesium bromide as described in Preparation 5 gave the title chromene as a golden yellow oil.

후처리

customas described in Preparation 5

출처 및 근거

ORD 기록: ord-5bd9a4ba3af041a393e3f50f4cf9bc71
출처 데이터셋: uspto-grants-1979_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04146539

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