2-benzyl 3-methyl (2S,3S,5S)-1-benzyl-5-tert-butoxypiperidine-2,3-dicarboxylate → HCID 67304647, 화합물

HRID 61476노트

반응식

HRID 61476 반응식
C([N:8]1[CH2:13][C@@H:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])[CH2:11][C@H:10]([C:19]([O:21][CH3:22])=[O:20])[C@H:9]1[C:23]([O:25]CC1C=CC=CC=1)=[O:24])C1C=CC=CC=1.[H][H]>CO.[Pd]>[C:15]([O:14][C@@H:12]1[CH2:13][NH:8][C@H:9]([C:23]([OH:25])=[O:24])[C@@H:10]([C:19]([O:21][CH3:22])=[O:20])[CH2:11]1)([CH3:18])([CH3:17])[CH3:16]

참가 물질

5

반응물 2

HCID 866214892-benzyl 3-methyl (2S,3S,5S)-1-benzyl-5-tert-butoxypiperidine-2,3-dicarboxylateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 67304647HCID 67304647, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of 2-benzyl 3-methyl(2S,3S,5S)-1-benzyl-5-tert-butoxypiperidine-2,3-dicarboxylate (80.0 mg, 0.000182 mol) in 5 mL of MeOH was hydrogenated in the presence of 10% Pd/C, under a balloon pressure of hydrogen, overnight. After filter off the catalyst, the filtration was concentrated to dry and used directly in next step (43 mg, 91.1%). MS (ESI): (M+H)+=260.1.

후처리

  1. filtrationAfter filter off the catalyst
  2. filtrationthe filtration
  3. concentrationwas concentrated
  4. customto dry

출처 및 근거

ORD 기록
ord-105de5df2a9f4ffba7eb14893705e4e2
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440958B2

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