Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Metoclopramide → HCID 13140663, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Metoclopramide | HCID 4168 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 2-(4-Chlorophenoxy)-2-methylpropanoyl chloride | HCID 2781312 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | HCID 13140663 | HCID 13140663 | 73.7% |
반응 단계
Metoclopramide (59.8 g.; 0.2 mole) and triethylamine (30.0 g; 0.3 mole) are dissolved in 400 ml. of chloroform. To this mixture there is added dropwise 2-(4-chlorphenoxy)-2-methylpropionic acid chloride (72.0 g.; 0.3 mole). The mixture is heated under reflux for two hours and is subsequently mixed with 100 ml. of 20% caustic soda solution and with water. After evaporation, the distillation residue is recrystallized from methanol whereby 73.2 g. (73.7% of theory) of 4-[2-(4-chlorphenoxy)isobutyroylamino]-5-chloro-2-methoxy-N-[2-(diethylamino)-ethyl]benzamide having a melting point of 120°-121° C. is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04146637 |
| 출처 데이터셋 | uspto-grants-1979_03 |
| ORD ID | ord-13329d2adcd34b1faab2c6dff917845c |
| 출처 메모 | uspto-grants-1979_03 |