2-Pyridinamine, 5-iodo- → HCID 43144875, 화합물
반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([O-:7])[CH:2]=1.[K+].[NH2:9][C:10]1[CH:15]=[CH:14][C:13](I)=[CH:12][N:11]=1>CC(N(C)C)=O>[NH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:7][C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)=[CH:12][N:11]=1참가 물질
4
실험 절차
3.3 G. of potassium 3-pyridinolate, 5.47 g. of 2-amino 5-iodopyridine and 1.78 g. of cuprous oxide in 150 ml. of dimethylacetamide are heated at reflux under a nitrogen atmosphere for 24 hours. The solvent is removed in vacuo and the residue is extracted with chloroform. Chromatography of the methylene chloride soluble portion with silica gel and elution with ethyl acetate yields 2-amino-5-(3-pyridyloxy) pyridine.
후처리
- temperatureat reflux under a nitrogen atmosphere for 24 hours
- customThe solvent is removed in vacuo
- extractionthe residue is extracted with chloroform
- washChromatography of the methylene chloride soluble portion with silica gel and elution with ethyl acetate
출처 및 근거
- ORD 기록
- ord-da16c0f3c4d344afa3daa26a7e35d28c
- 출처 데이터셋
- uspto-grants-1979_03
- 특허 번호
- US04146642
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