Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dicyclohexylcarbodiimide → N-(3-methoxycarbonyl-2-methylpropanoyl)-L-alanine benzyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | 4-Methyl hydrogen 2-methylenesuccinate | HCID 81791 | — |
| 반응물 | benzyl (2S)-2-aminopropanoate | HCID 726858 | — |
| 반응물 | 4-Methoxy-2-methyl-4-oxobutanoic acid | HCID 4563901 | — |
| 반응물 | HCID 178418300 | HCID 178418300 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | N-(3-methoxycarbonyl-2-methylpropanoyl)-L-alanine benzyl ester | HCID 53826083 | — |
반응 단계
L-alanine benzyl ester (44.7 g.) and hydroxybenzotriazole (34 g.) are dissolved in dioxane (750 ml.) and the solution is chilled with stirring in an ice-water bath. Dicyclohexylcarbodiimide (51.5 g.) and 3-methoxycarbonyl-2-methylpropanoic acid (36 g.), prepared by hydrogenation of 3-methoxycarbonyl-2-methylene propanoic acid, are added in that order and the mixture is stirred at room temperature for 18 hours. The precipitate is filtered off, and the filtrate is concentrated to dryness in vacuo. The residue is dissolved in ethyl acetate and washed neutral. The ethyl acetate is dried over magnesium sulfate and concentrated to dryness in vacuo to yield N-(3-methoxycarbonyl-2-methylpropanoyl)-L-alanine benzyl ester.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04146641 |
| 출처 데이터셋 | uspto-grants-1979_03 |
| ORD ID | ord-68bfb8aa63d5422f963f4c15209b9cb2 |
| 출처 메모 | uspto-grants-1979_03 |