N,N-Diethyl-2-oxiranemethanamine → 2-Amino-5-diethylaminomethyl-2-oxazoline

HRID 615131노트

반응식

HRID 615131 반응식
[CH2:1]([N:3]([CH2:8][CH3:9])[CH2:4][CH:5]1[O:7][CH2:6]1)[CH3:2].[Na].[N:11]#[C:12][NH2:13]>CO>[NH2:11][C:12]1[O:7][CH:5]([CH2:4][N:3]([CH2:8][CH3:9])[CH2:1][CH3:2])[CH2:6][N:13]=1

참가 물질

4

반응물 2

HCID 95611N,N-Diethyl-2-oxiranemethanamineHCID 57375518Cyanamidnatrium

생성물 1

HCID 3958562-Amino-5-diethylaminomethyl-2-oxazoline수율 68%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

0.2 Mole of the 1-diethylamino-2,3-epoxypropane thus prepared is added, drop by drop, to 12.8 g of the cyanamide monosodium derivative dissolved in 200 cc of anhydrous methanol with vigorous stirring. After 15 hours of stirring at ambient temperature, the methanol is evaporated and the residue picked up with 300 cc of ether. The precipitate is eliminated by filtering. The ether phase is washed twice with 2 cc of water then dried on Na2SO4 after decanting. The ether is evaporated under low pressure. The resulting oily phase crystallizes after washing with boiling heptane. 2-Amino-5-diethylaminomethyl-2-oxazoline is thus obtained with a yield of 68%. It is purified by recrystallization in heptane.

후처리

  1. additionis added
  2. customthe methanol is evaporated
  3. filtrationby filtering
  4. washThe ether phase is washed twice with 2 cc of water
  5. customthen dried on Na2SO4
  6. customafter decanting
  7. customThe ether is evaporated under low pressure
  8. customThe resulting oily phase crystallizes
  9. washafter washing with boiling heptane

출처 및 근거

ORD 기록
ord-c4e93a626ceb434d8587e3af3eae472f
출처 데이터셋
uspto-grants-1985_02
특허 번호
US04497812

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