Methanol → methyl 2-amino-3-(1H-indol-3-yl)propanoate hydrochloride

HRID 615255

반응식

HRID 615255 반응식
[NH2:1][CH:2]([C:13]([OH:15])=[O:14])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.S(Cl)([Cl:18])=O.[CH3:20]O>>[ClH:18].[CH3:20][O:14][C:13](=[O:15])[CH:2]([CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1)[NH2:1]

참가 물질

4

반응물 3

HCID 887MethanolHCID 1148Dl-TryptophanHCID 24386Thionyl Chloride

생성물 1

HCID 2827264methyl 2-amino-3-(1H-indol-3-yl)propanoate hydrochloride

실험 절차

50 g of DL-tryptophan available from Nakarai Chemicals, Kyoto, Japan, was suspended in 500 ml of methanol and 40 ml of thionyl chloride was dropwise added thereto while vigorously stirring. The reaction was exothermic and the reaction mixture was allowed to be refluxed for 10 hours while stirring. Then, the solvent was distilled off and the resultant residue was washed with diethylether. Thus, DL-tryptophan methylester hydrochloride was obtained in the form of white crystals.

후처리

  1. temperatureto be refluxed for 10 hours
  2. stirringwhile stirring
  3. distillationThen, the solvent was distilled off
  4. washthe resultant residue was washed with diethylether

출처 및 근거

ORD 기록
ord-470d02e5100e4955bcb4e8f5514d2070
출처 데이터셋
uspto-grants-1985_02
특허 번호
US04497957

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