Cyanogen Bromide → 2,2-Dimethoxy-1-methylpropylcyanamide

HRID 615262노트

반응식

HRID 615262 반응식
[N:1]#[C:2]Br.[CH3:4][O:5][C:6]([O:11][CH3:12])([CH3:10])[CH:7]([NH2:9])[CH3:8]>O.CO>[CH3:4][O:5][C:6]([O:11][CH3:12])([CH3:10])[CH:7]([NH:9][C:2]#[N:1])[CH3:8]

참가 물질

5

반응물 2

HCID 10476Cyanogen BromideHCID 158518261-Methyl-2,2-dimethoxypropylamine

생성물 1

HCID 201644792,2-Dimethoxy-1-methylpropylcyanamide

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매2회

실험 절차

Cyanogen bromide (424 mg., 4 m moles) was added to a solution of 2,2-dimethoxy-1-methylpropylamine (266 mg., 2 m moles) and KHCO3 (400 mg., 4 m moles) in a mixture of water (2 ml.) and methanol (4 ml.). After 15 minutes the mixture was poured into water (150 ml.) and the mixture extracted with CH2Cl2. The extract was washed with water and brine, dried (MgSO4) and evaporated to dryness to give 2,2-dimethoxy-1-methylpropylcyanamide as a pale yellow oil (280 mg., 88%) having the following n.m.r. spectrum in CDCl3 : 1.15 (s, 3H), 1.18 (d, 3H); 3.15 (s, 6H); 3.0-3.6 (m, 1H); 4.0 (m, 1H).

후처리

  1. extractionthe mixture extracted with CH2Cl2
  2. washThe extract was washed with water and brine
  3. dry with materialdried (MgSO4)
  4. customevaporated to dryness

출처 및 근거

ORD 기록
ord-b33e2376a4334f72a40abad4790fb097
출처 데이터셋
uspto-grants-1985_02
특허 번호
US04497949

반응 노트

불러오는 중…