Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 2(R)-ethyl 1-[(1-phenyl 3-isoquinolyl) carbonyl]piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Ethyl chloroformate | HCID 10928 | — |
| 반응물 | 1-Phenylisoquinoline-3-carboxylic acid | HCID 407896 | — |
| 반응물 | (R)-2-Ethylpiperidine hydrochloride | HCID 18596119 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2(R)-ethyl 1-[(1-phenyl 3-isoquinolyl) carbonyl]piperidine | HCID 24842682 | 57.9% |
반응 단계
Operations are carried out as for Example 7, starting from 2.5 g of 1-phenyl isoquinoline 3-carboxylic acid, 2.86 g of triethylamine, 1.24 g of ethyl chloroformate and 1.93 g of 2(R)-ethyl piperidine hydrochloride in 100 ml of toluene. After chromatography, 2 g of 2(R)-ethyl 1-[(1-phenyl 3-isoquinolyl) carbonyl]piperidine in the form of oil are obtained. αD26 =+1.4° (2% in ethanol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04499094 |
| 출처 데이터셋 | uspto-grants-1985_02 |
| ORD ID | ord-4e313db4a4574cf1a2f5d32a6112034f |
| 출처 메모 | uspto-grants-1985_02 |