Triethylamine → HCID 20407006, 화합물

HRID 615537노트

반응식

HRID 615537 반응식
[CH3:1][C:2]([C:5]1[CH:9]=[C:8]([NH2:10])[O:7][N:6]=1)([CH3:4])[CH3:3].C(N(CC)CC)C.[CH3:18][CH:19]([CH2:23][CH2:24][Cl:25])[C:20](Cl)=[O:21]>C(OCC)(=O)C>[Cl:25][CH2:24][CH2:23][CH:19]([CH3:18])[C:20]([NH:10][C:8]1[O:7][N:6]=[C:5]([C:2]([CH3:4])([CH3:3])[CH3:1])[CH:9]=1)=[O:21]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 20956943-Tert-butyl-1,2-oxazol-5-amineHCID 137705824-Chloro-2-methylbutanoyl chloride

생성물 1

HCID 20407006HCID 20407006, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a stirred solution of 7 g of 3-(1,1-dimethylethyl)-5-aminoisoxazole dissolved in 50 ml ethyl acetate was added 5.05 g of triethylamine at room temperature. As the solution continued to stir, 8 g of 2-methyl-4-chlorobutyric acid chloride was added to the reaction mixture over a 15 minute period. The reaction was allowed to stir for about 3 days and the precipitated triethylamine hydrochloride salt was collected by filtration and washed with ethyl acetate. The solvent was evaporated from the filtrate under reduced pressure and the residue was recrystallized from diethyl ether to afford 4-chloro-N-[3-(1,1-dimethylethyl)-5-isoxazolyl]-2-methylbutanamide as a solid. mp 135°-137° C.

후처리

  1. stirringto stir for about 3 days
  2. filtrationthe precipitated triethylamine hydrochloride salt was collected by filtration
  3. washwashed with ethyl acetate
  4. customThe solvent was evaporated from the filtrate under reduced pressure
  5. customthe residue was recrystallized from diethyl ether

출처 및 근거

ORD 기록
ord-148b9ed18c734c2f92180adc2ac95b53
출처 데이터셋
uspto-grants-1985_02
특허 번호
US04500343

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