Potassium Hydroxide → HCID 20407005, 화합물

HRID 615538노트

반응식

HRID 615538 반응식
Cl[CH2:2][CH2:3][CH:4]([CH3:17])[C:5]([NH:7][C:8]1[O:12][N:11]=[C:10]([C:13]([CH3:16])([CH3:15])[CH3:14])[CH:9]=1)=[O:6].[OH-].[K+]>O.C(O)C>[CH3:14][C:13]([C:10]1[CH:9]=[C:8]([N:7]2[CH2:2][CH2:3][CH:4]([CH3:17])[C:5]2=[O:6])[O:12][N:11]=1)([CH3:16])[CH3:15]

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 20407006HCID 20407006, 화합물

생성물 1

HCID 20407005HCID 20407005, 화합물수율 87.3%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매2회

실험 절차

Two grams of 4-chloro-N-[3-(1,1-dimethylethyl)-5-isoxazolyl]-2-methylbutanamide was added by portion to a stirring solution of 0.6 g of powdered potassium hydroxide dissolved in 2 ml of water and 5 ml of ethanol. The reaction mixture was heated to reflux for 15 minutes, cooled and poured into 20 ml of water. The precipitated solid was collected by filtration to afford 1.5 g of 1-[3-(1,1-dimethylethyl)-5-isoxazolyl]-3-methyl-2-pyrrolidinone. Yield 87%. mp 73°-75° C.

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 15 minutes
  3. temperaturecooled
  4. filtrationThe precipitated solid was collected by filtration

출처 및 근거

ORD 기록
ord-0e6ba941093e4ec8bc70bd3a7e63d242
출처 데이터셋
uspto-grants-1985_02
특허 번호
US04500343

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