Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 615567생성일: 2026년 10월 25일
Hydrochloric Acid → 5-(4-Methyl-4-oxidopiperazino)-imidazo[2,1-b][1,3,5]benzothiadiazepine hydrochloride
https://huagongshe.com/reaction/615567
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Pentiapine | HCID 54742 | — |
| 반응물 | m-Chloroperbenzoic acid | HCID 70297 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 5-(4-Methyl-4-oxidopiperazino)-imidazo[2,1-b][1,3,5]benzothiadiazepine hydrochloride | HCID 15586419 | — |
반응 단계
To the solution of 88 mg of 5-(4-methylpiperazino)-imidazo[2,1-b][1,3,5]benzothiadiazepine in 1 ml of methylene chloride, 74 mg of m-chloroperbenzoic acid are added at 0° C. The mixture is stirred at 0° C. overnight; this is diluted with 1 ml of ether, one equivalent of ethereal hydrochloric acid solution is added and the resulting precipitate is collected. Recrystallization from methanol-ethyl acetate yields 5-(4-methyl-4-oxidopiperazino)-imidazo[2,1-b][1,3,5]benzothiadiazepine hydrochloride, melting at 155° with decomposition.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US04500472 |
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| 출처 데이터셋 | uspto-grants-1985_02 |
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| ORD ID | ord-9d94d3beb4a14d7f88f3697346fc344c |
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| 출처 메모 | uspto-grants-1985_02 |
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