Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isopropyl chloroacetate → tert-butyl 5-(2-(3-(2-isopropoxy-2-oxoethoxy)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isopropyl chloroacetate | HCID 7759 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1H-Indazole-1-carboxylic acid, 5-[[2-(3-hydroxyphenyl)-4-quinazolinyl]amino]-, 1,1-dimethylethyl ester | HCID 56949454 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | tert-butyl 5-(2-(3-(2-isopropoxy-2-oxoethoxy)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate | HCID 59361962 | — |
반응 단계
A suspension of tert-butyl 5-(2-(3-hydroxyphenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate (120 mg, 0.26 mmol), isopropyl 2-chloroacetate (45 mL, 0.36 mmol), K2CO3 (125 μL, 0.24 mmol), in DMF (5 mL) stirred at RT for 2 h. Concentrated in vacuo to afford the crude tert-butyl 5-(2-(3-(2-isopropoxy-2-oxoethoxy)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate. (0.26 mmol)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09440961B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-6f207ee295f0458e972152cb87e98315 |
| 출처 메모 | uspto-grants-2016_09 |