1-Diethoxyphosphorylethanamine → HCID 12673131, 화합물

반응식

[NH2:1][CH:2]([P:4](=[O:11])([O:8][CH2:9][CH3:10])[O:5][CH2:6][CH3:7])[CH3:3].[CH:12](CC(OC(=O)CC=O)=O)=[O:13]>>[CH:12]([NH:1][CH:2]([P:4](=[O:11])([O:5][CH2:6][CH3:7])[O:8][CH2:9][CH3:10])[CH3:3])=[O:13]

참가 물질

반응물 2

HCID 51498581-Diethoxyphosphorylethanamine

HCID 53941097HCID 53941097, 화합물

생성물 1

HCID 12673131HCID 12673131, 화합물

반응 조건

온도: 120 °C

실험 절차

A mixture of 3.6 g of diethyl α-aminoethyl-phosphonate prepared by the process of Chalmers et al, J.A.C.S., Vol 75 (1953), p. 5278 and 2 g of formylacetic acid anhydride stood overnight at room temperature and was then heated at 120° C. under a pressure of 0.5 to 1 mm Hg for 15 to 20 minutes. The residue was distilled to obtain pure diethyl 1-(N-formylamino)-ethyl-phosphonate with a boiling point of 148°~150° at 0.5 mm Hg which was used as is for the next step.

후처리

customprepared by the process of Chalmers et al, J.A.C.S
distillationThe residue was distilled

출처 및 근거

ORD 기록: ord-e18a4461d52f4ca7a47cfe5eb575f40f
출처 데이터셋: uspto-grants-1985_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04501701

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