Dicyclohexylcarbodiimide → N-[(3-pyridyl)methyl]-N-(4-fluorophenyl)-alpha-(n-butylthio)acetamide

HRID 615870노트

반응식

HRID 615870 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[CH:4][CH:3]=1.[CH2:16]([S:20][CH2:21][C:22](O)=[O:23])[CH2:17][CH2:18][CH3:19].C1(N=C=NC2CCCCC2)CCCCC1>ClCCl>[N:12]1[CH:13]=[CH:14][CH:15]=[C:10]([CH2:9][N:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)[C:22](=[O:23])[CH2:21][S:20][CH2:16][CH2:17][CH2:18][CH3:19])[CH:11]=1

참가 물질

5

반응물 3

HCID 10868DicyclohexylcarbodiimideHCID 88607(Butylthio)acetic acidHCID 645683N-(4-Fluorophenyl)-3-pyridinemethanamine

생성물 1

HCID 13652430N-[(3-pyridyl)methyl]-N-(4-fluorophenyl)-alpha-(n-butylthio)acetamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

N-[(3-pyridyl)methyl]-N-(4-fluorophenyl)-α-(n-butylthio)acetamide was prepared by the method of Example 2 by reacting 10.1 g. of N-(4-fluorophenyl)-[(3-pyridyl)methyl]amine with 7.4 g. of α-(n-butylthio)acetic acid and 10.3 g. of N,N'-dicyclohexylcarbodiimide in 250 ml. of dichloromethane. Weight 6.5 g. as an oil.

출처 및 근거

ORD 기록
ord-a5fb947f742b433fb5addfcae35a70de
출처 데이터셋
uspto-grants-1985_02
특허 번호
US04501746

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