Ammonium Hydroxide → 4-Methyl-2-phenyloxazole-5-carboxamide

HRID 616014노트

반응식

HRID 616014 반응식
[OH-].[NH4+:2].[C:3]([C:8]1[O:12][C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[N:10][C:9]=1[CH3:19])(OCC)=[O:4]>C(O)C>[C:3]([C:8]1[O:12][C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[N:10][C:9]=1[CH3:19])(=[O:4])[NH2:2]

참가 물질

4

반응물 2

HCID 14923Ammonium HydroxideHCID 12282208ethyl 4-methyl-2-phenyl-1,3-oxazole-5-carboxylate

생성물 1

HCID 727634-Methyl-2-phenyloxazole-5-carboxamide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

150 Ml. (2.5 mole) of concentrated ammonium hydroxide is added dropwise to a solution of 10 g. (0.0434 mole) of 5-carbethoxy-2-phenyl-4-methyloxazole in 150 ml. of 95% ethanol. The mixture is stirred three days at room temperature, then it is concentrated to 50 ml. by evaporating the ethanol and chilled. The precipitated product is filtered, washed, dried over sodium sulfate and recrystallized from methanol; yield 3.7 g. of the title compound; m.p. 187°-190°.

후처리

  1. concentrationit is concentrated to 50 ml
  2. customby evaporating the ethanol
  3. temperaturechilled
  4. filtrationThe precipitated product is filtered
  5. washwashed
  6. dry with materialdried over sodium sulfate
  7. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-41a18a3b133e47a28f4c0d53ffcb7d5b
출처 데이터셋
uspto-grants-1978_02
특허 번호
US04072689

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