N-(4-chlorobenzenesulphonyl)-N',S-dimethylisothiourea → HCID 178485013, 화합물

HRID 616169노트

반응식

HRID 616169 반응식
[CH3:1][C:2]1[N:3]=[CH:4][NH:5][C:6]=1[CH2:7][S:8][CH2:9][CH2:10][NH2:11].[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([S:19]([NH:22][C:23](=[N:26][CH3:27])SC)(=[O:21])=[O:20])=[CH:15][CH:14]=1>C(#N)C>[Cl:12][C:13]1[CH:14]=[CH:15][C:16]([S:19]([NH:22][C:23]([NH:26][CH3:27])=[N:11][CH2:10][CH2:9][S:8][CH2:7][C:6]2[NH:5][CH:4]=[N:3][C:2]=2[CH3:1])(=[O:20])=[O:21])=[CH:17][CH:18]=1

참가 물질

4

반응물 2

HCID 22756462N-(4-chlorobenzenesulphonyl)-N',S-dimethylisothioureaHCID 178433288HCID 178433288, 화합물

생성물 1

HCID 178485013HCID 178485013, 화합물수율 59.1%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of 4-methyl-5-((2-aminoethyl)thiomethyl)imidazole (3.33 g.) and N-(4-chlorobenzenesulphonyl)-N' ,S-dimethylisothiourea (5.40 g.) in acetonitrile was heated under reflux for 24 hours. Concentration, followed by recrystallisation from aqueous ethanol afforded N-(4-chlorobenzenesulphonyl)-N'-methyl-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine (4.6 g.), m.p. 153°-154°.

후처리

  1. temperatureunder reflux for 24 hours
  2. concentrationConcentration
  3. customfollowed by recrystallisation from aqueous ethanol

출처 및 근거

ORD 기록
ord-29a4b0ac86234d5c9a9326ce1c23113a
출처 데이터셋
uspto-grants-1978_02
특허 번호
US04072748

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